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The Prognostic Value Of Microsatellite Instability, KRAS, BRAF And PIK3CA Mutations In Stage II Colon Cancer Patients

F Jeroen Vogelaar, Felice N van Erning, Marlies S Reimers, Hans van der Linden, Hans Pruijt, Adriaan J C van den Brule, and Koop Bosscha In the era of personalized cancer medicine, identifying mutations within patient tumors plays an important role in defining high-risk stage II colon cancer patients. The prognostic role of BRAF V600E mutation, ... more...

Posted by Sheila Platt on 2015 May 9, 2016 12:40 PM CDT

Targeting The NLRP3 Inflammasome To Reduce Diet-Induced Metabolic Abnormalities In Mice

Fausto Chiazza, Aurélie Couturier-Maillard, Elisa Benetti, Raffaella Mastrocola, Debora Nigro, Juan C Cutrin, Loredana Serpe, Manuela Aragno, Roberto Fantozzi, Bernard Ryffel, Christoph Thiemermann, and Massimo Collino Although the molecular links underlying the causative relationship between chronic low-grade inflammation and ... more...

Posted by Sheila Platt on 2015 May 9, 2016 12:25 PM CDT

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GPR84 And TREM-1 Signaling Contribute To The Pathogenesis Of Reflux Esophagitis

Heba Abdel-Aziz, Mathias Schneider, Winfried Neuhuber, Abdel Meguid Kassem, Saleem Khailah, Jürgen Müller, Hadeel Gamal Eldeen, Ahmed Khairy, Mohamed T Khayyal, Anastasiia Shcherbakova, Thomas Efferth, and Gudrun Ulrich-Merzenich Gastro-esophageal reflux disease (GERD) is one of the most common disorders in gastroenterology. Patients ... more...

Posted by Sheila Platt on 2015 May 9, 2016 10:10 AM CDT

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Intravenous Immunoglobulin With Enhanced Polyspecificity Improves Survival In Experimental Sepsis And Aseptic Systemic Inflammatory Response Syndromes

Iglika Djoumerska-Alexieva, Lubka Roumenina, Anastas Pashov, Jordan Dimitrov, Maya Hadzhieva,Sandro Lindig, Elisaveta Voynova, Petya Dimitrova, Nina Ivanovska, Clemens Bockmeyer, Zvetanka Stefanova, Catherine Fitting, Markus Bläss, Ralf Claus, Stephan von Gunten, Srini Kaveri, Jean-Marc Cavaillon, Michael Bauer, and Tchavdar ... more...

Posted by Sheila Platt on 2015 Mar 31, 2016 10:52 AM CDT

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Simvastatin And A Plant Galactolipid Protect Animals From Septic Shock By Regulating Oxylipin Mediator Dynamics Through The MAPK-cPLA2 Signaling Pathway

Maria Karmella Apaya, Chih-Yu Lin, Ching-Yi Chiou, Chung-Chih Yang, Chen-Yun Ting, and Lie-Fen Shyur Sepsis remains a major medical issue despite decades of research. Identification of important inflammatory cascades and key molecular mediators are crucial for developing intervention and prevention strategies. In this study, we conducted a ... more...

Posted by Sheila Platt on 2015 Mar 31, 2016 9:09 AM CDT

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Erythropoietin For The Treatment Of Subarachnoid Hemorrhage: A Feasible Ingredient For A Successful Medical Recipe

Giovanni Grasso, Giovanni Tomasello, Marcello Noto, Concetta Alafaci, and Francesco Cappello Subarachnoid hemorrhage (SAH) following aneurysm bleeding accounts for 6% to 8% of all cerebrovascular accidents. Although an aneurysm can be effectively managed by surgery or endovascular therapy, delayed cerebral ischemia is diagnosed in a high ... more...

Posted by Sheila Platt on 2015 Mar 28, 2016 2:31 PM CDT

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ARA290 Improves Insulin Release And Glucose Tolerance In Type 2 Diabetic Goto-Kakizaki Rats

Carole Muller, Kamal Yassin, Luo-Sheng Li, Magnus Palmblad, Suad Efendic, Per-Olof Berggren, Anthony Cerami, Michael Brines, and Claes-Göran Östenson Effects of ARA290 on glucose homeostasis were studied in type 2 diabetic Goto-Kakizaki (GK) rats. In GK rats receiving ARA290 daily for up to 4 wks, plasma glucose concentrations were lower after 3 ... more...

Posted by Sheila Platt on 2015 Mar 24, 2016 12:07 PM CDT

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Alternative Mechanism For White Adipose Tissue Lipolysis After Thermal Injury

Li Diao,David Patsouris, Ali-Reza Sadri, Xiaojing Dai,Saeid Amini-Nik, and Marc G Jeschke Extensively burned patients often suffer from sepsis, a complication that enhances postburn hypermetabolism and contributes to increased incidence of multiple organ failure, morbidity and mortality. Despite the clinical importance of burn sepsis, the ... more...

Posted by Sheila Platt on 2015 Mar 24, 2016 11:00 AM CDT

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HMGB1 Mediates Anemia Of Inflammation In Murine Sepsis Survivors

Sergio I Valdés-Ferrer, Julien Papoin, Meghan E Dancho, Peder S Olofsson, Jianhua Li, Jeffrey M Lipton, Patricia Avancena, Huan Yang, Yong-Rui Zou, Sangeeta S Chavan, Bruce T Volpe, Sara Gardenghi, Stefano Rivella, Betty Diamond, Ulf Andersson, Bettie M Steinberg, Lionel Blanc, and Kevin J Tracey Patients surviving sepsis develop anemia, but the ... more...

Posted by Sheila Platt on 2015 Mar 17, 2016 10:06 AM CDT

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AMP-Activated Protein Kinase And Glycogen Synthase Kinase 3β Modulate The Severity Of Sepsis-Induced Lung Injury

Zhongyu Liu, Nathaniel Bone, Shaoning Jiang, Dae Won Park, Jean-Marc Tadie, Jessy Deshane, Cilina Ann Rodriguez, Jean-Francois Pittet, Edward Abraham, and Jaroslaw W Zmijewski Alterations in metabolic and bioenergetic homeostasis contribute to sepsis-mediated organ injury. However, how AMP-activated protein kinase (AMPK), a major sensor ... more...

Posted by Sheila Platt on 2015 Mar 14, 2016 2:52 PM CDT

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Cryopreserved Interleukin-4–Treated Macrophages Attenuate Murine Colitis in an Integrin a7–Dependent Manner

Gabriella Leung, Björn Petri, José Luis Reyes, Arthur Wang, Jordan Iannuzzi, and Derek M McKay The adoptive transfer of alternatively activated macrophages (AAMs) has proven to attenuate inflammation in multiple mouse models of colitis; however, the effect of cryopreservation on AAMs, the ability of previously frozen AAMs to block ... more...

Posted by Sheila Platt on 2015 Mar 10, 2016 3:33 PM CST

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Aloperine Protects Mice Against Ischemia-Reperfusion (IR)-Induced Renal Injury By Regulating PI3K/AKT/mTOR Signaling And AP-1 Activity

Shuang Hu, Yuxing Zhang, Meng Zhang, Yanchao Guo, Ping Yang, Shu Zhang, Sakine Simsekyilmaz, Jun-Fa Xu, Jinxiu Li, Xudong Xiang, Qilin Yu, and Cong-Yi Wang Aloperine is a quinolizidine alkaloid extracted from the leaves of Sophora plants. It has been recognized with the potential to treat inflammatory and allergic diseases as well as tumors. In this ... more...

Posted by Sheila Platt on 2015 Mar 10, 2016 2:54 PM CST

Early And Short-term Triiodothyronine Supplementation Prevents Adverse Postischemic Cardiac Remodeling: Role Of Transforming Growth Factor-a1 And Antifibrotic MiRNA Signaling

Giuseppina Nicolini, Francesca Forini, Claudia Kusmic, Letizia Pitto, Laura Mariani, and Giorgio Iervasi Activation of transforming growth factor (TGF)-β1 signaling in the ischemia/reperfusion (I/R) injured myocardium leads to dysregulation of miR-29-30-133, favoring the profibrotic process that leads to adverse cardiac remodeling ... more...

Posted by Sheila Platt on 2015 Mar 8, 2016 1:20 PM CST

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Peroxisome Proliferator–Activated Receptor α Protects Renal Tubular Cells From Gentamicin-Induced Apoptosis Via Upregulating Na+/H+ Exchanger NHE1

Cheng-Hsien Chen, Tso-Hsiao Chen, Mei-Yi Wu, Jia-Rung Chen, Li-Yu Hong, Cai-Mei Zheng, I-Jen Chiu, Yuh-Feng Lin, and Yung-Ho Hsu Peroxisome proliferator–activated receptor (PPAR)-α is a transcription factor that has been reported to inhibit gentamicin-induced apoptosis in renal tubular cells. However, the antiapoptotic mechanism of PPARα ... more...

Posted by Sheila Platt on 2015 Mar 8, 2016 1:07 PM CST

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Renal Integrin-Linked Kinase Depletion Induces Kidney cGMP-Axis Upregulation: Consequences on Basal and Acutely Damaged Renal Function

José Luis Cano-Peñalver, Mercedes Griera, Andrea García-Jerez, Marco Hatem-Vaquero, María Piedad Ruiz-Torres, Diego Rodríguez-Puyol, Sergio de Frutos, and Manuel Rodríguez-Puyol Soluble guanylyl cyclase (sGC) is activated by nitric oxide (NO) and produces cGMP, which activates cGMP-dependent protein kinases (PKG) and is hydrolyzed by ... more...

Posted by Leah Caracappa on 2015 Mar 2, 2016 12:56 PM CST

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Efficacy Of Combined Histone Deacetylase And Checkpoint Kinase Inhibition In A Preclinical Model Of Human Burkitt Lymphoma

YanGuo Kong, Gustavo A Barisone, Ranjit S Sidhu, Robert T O’Donnell, and Joseph M Tuscano Checkpoint kinase inhibition has been studied as a way of enhancing the effectiveness of DNA-damaging agents. More recently, histone deacetylase inhibitors have shown efficacy in several cancers, including non-Hodgkin lymphoma. To evaluate the ... more...

Posted by Sheila Platt on 2015 Feb 25, 2016 1:15 PM CST

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Protective Mechanisms of Hypothermia in Liver Surgery and Transplantation

Pim B Olthof, Megan J Reiniers, Marcel C Dirkes, Thomas M van Gulik, Michal Heger, and Rowan F van Golen Hepatic ischemia/reperfusion (I/R) injury is a side effect of major liver surgery that often cannot be avoided. Prolonged periods of ischemia put a metabolic strain on hepatocytes and limit the tolerable ischemia and preservation times during ... more...

Posted by Sheila Platt on 2015 Feb 25, 2016 1:05 PM CST

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Downregulation Of MiRNAs During Delayed Wound Healing In Diabetes: Role Of Dicer

Sushant Bhattacharya, Rangoli Aggarwal, Vijay Pal Singh, Srinivasan Ramachandran, and Malabika Datta Delayed wound healing is a major complication associated with diabetes and is a result of a complex interplay among diverse deregulated cellular parameters. Although several genes and pathways have been identified to be mediating impaired ... more...

Posted by Sheila Platt on 2015 Feb 25, 2016 12:50 PM CST

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Biomarkers For Bone Tumors: Discovery From Genomics And Proteomics Studies And Their Challenges

Wan I Wan-Ibrahim, Vivek A Singh, Onn H Hashim, and Puteri S Abdul-Rahman Diagnosis of bone tumor currently relies on imaging and biopsy, and hence, the need to find less invasive ways for its accurate detection. More recently, numerous promising deoxyribonucleic acid (DNA) and protein biomarkers with significant prognostic, diagnostic and/or ... more...

Posted by Sheila Platt on 2015 Feb 25, 2016 12:38 PM CST

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BACE-1, PS-1 And SAPPa Levels Are Increased In Plasma From Sporadic Inclusion Body Myositis Patients: Surrogate Biomarkers Among Inflammatory Myopathies

Marc Catalán-García, Glòria Garrabou, Constanza Morén, Mariona Guitart-Mampel, Ingrid Gonzalez-Casacuberta, Adriana Hernando, Jose Miquel Gallego-Escuredo, Dèlia Yubero, Francesc Villarroya, Raquel Montero, Albert Selva O-Callaghan, Francesc Cardellach, and Josep Maria Grau Sporadic inclusion body myositis (sIBM) is a rare disease ... more...

Posted by Sheila Platt on 2015 Feb 22, 2016 1:45 PM CST

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