A Longitudinal, Integrated, Clinical, Histological and mRNA Profiling Study of Resistance Exercise in Myositis

Gustavo A Nader, Maryam Dastmalchi, Helene Alexanderson, Cecilia Grundtman, Ramkishore Gernapudi, Mona Esbjörnsson, Zuyi Wang, Johan Rönnelid, Eric P Hoffman, Kanneboyina Nagaraju, and Ingrid E Lundberg

Polymyositis (PM) and dermatomyositis (DM) are chronic, autoimmune skeletal muscle disorders characterized by weakness, infiltration by mononuclear inflammatory cells and fibrosis. Despite current pharmacological treatment, many patients are left with impaired muscle function. While recent studies have shown moderate exercise training in combination with immunosuppressive drugs may improve muscle performance, the molecular mechanisms underlying the exercise-associated clinical improvements remain poorly understood. In the present study, Nader et al. investigate the underlying mechanisms responsible for the beneficial effects of resistance exercise in autoimmune inflammatory myopathy (AIM) patients using genome wide mRNA profiles. Changes in gene expression reported are in agreement with performance improvements induced by exercise and suggest resistance exercise training can induce a reduction in inflammation and fibrosis in skeletal muscle. High-throughput analysis of skeletal muscle gene expression may provide useful information for identification of new disease biomarkers and targets for pharmacological intervention of AIM patients.

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Posted by MolMed Admin on Dec 27, 2010 3:15 PM CST