Phosphorylation of Extracellular Signal-Regulated Kinase (ERK)-1/2 Is Associated with the Downregulation of Peroxisome Proliferator–Activated Receptor (PPAR)-γ during Polymicrobial Sepsis

Jennifer M Kaplan, Paul W Hake, Alvin Denenberg, Marchele Nowell, Giovanna Piraino, and Basilia Zingarelli

Sepsis, an overwhelming inflammatory response to infection or injury, may lead to shock, multiple organ failure and death. Peroxisome proliferator-activated receptor-γ (PPARγ) is a transcription factor which regulates inflammation. Post-translational modifications to PPARγ regulate its function, potentially affecting inflammation. In this work, Kaplan et al. investigated the kinetics of altered PPARγ expression and activation in a model of polymicrobial sepsis. Data demonstrate PPARγ is reduced in immunomodulatory and parenchymal cells during polymicrobial sepsis. Restoration of PPARγ correlates with an increase in levels of the antiinflammatory adipokine, adiponectin. These results provide a mechanism through which a decrease in PPARγ in sepsis may be partially explained and support the notion that additional studies investigating the molecular link between adipokines and the inflammatory response in sepsis are warranted.

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Posted by MolMed Admin on Nov 5, 2010 12:00 AM CDT