Early Increase of Plasma Homocysteine in Sepsis Patients with Poor Outcome

Martin Ploder, Katharina Kurz, Andreas Spittler, Gabriele Neurauter, Erich Roth, and Dietmar Fuchs

Hyperhomocysteinaemia, or increased levels of homocysteine in the blood, is an established risk factor for coronary artery disease, which occurs when dietary supply with folate and/or vitamin B12 is inadequate. Increased homocysteine in the blood may lead to formation of blood clots, resulting in heart attack or stroke. Homocysteine also acts as a proinflammatory mediator and may therefore play a role when the immune system is stimulated, such as in trauma or sepsis. Since no major studies have investigated homocysteine concentrations in septic patients, Ploder et al. investigated whether hyperhomocysteinemia may develop in this cohort despite administration of enteral nutrition. Results indicate increased levels of homocysteine are associated with poor patient outcomes. This may be due to the increased demand of B-vitamins associated with immunopathogenetic mechanisms. Although preliminary, this work suggests B-vitamin supplementation during inflammatory conditions should be further explored.

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Posted by MolMed Admin on Nov 6, 2010 12:00 AM CDT