Genome-Wide Association for Smoking Cessation Success in a Trial of Precessation Nicotine Replacement

George R Uhl, Tomas Drgon, Catherine Johnson, Marco F Ramoni, Frederique M Behm, and Jed E Rose

Cigarette smoking is a significant cause of premature death and disease. Although abstinence reduces risks to smokers, success rates following attempts to quit smoking remain modest. One year after unaided attempts to quit smoking, abstinence rates are less than 5%. In the current study, Uhl et al. report genome wide association studies of smoking cessation success in individually-genotyped European-American participants in a smoking cessation trial that examined effects of pre-cessation nicotine replacement therapy. Results identified a set of single nucleotide polymorphisms (SNPs) that overlap with prior datasets and likely identify a network of SNPs and genes with true biological relationships. Most of these genes are expressed in the brain and are related to neurotransmission processes, as may be expected for addiction-related traits. These results add to support for personalized approaches to smoking cessation treatment and contribute to studies that document molecular genetic contributions to the ability to quit smoking.

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Posted by MolMed Admin on Dec 1, 2010 12:00 AM CST