Caveolin-1 as a Novel Indicator of Wound-Healing Capacity in Aged Human Corneal Epithelium

Ji Heon Rhim, Jae Hoon Kim, Eui-Ju Yeo, Jae Chan Kim, and Sang Chul Park

Postoperative care for the elderly requires special attention with respect to wound healing time. While several factors have been found to play roles during wound healing, the molecular mechanisms responsible for age-dependent delay in wound healing have not been well defined. Caveolin is a principal structural component of caveolae membranes. Levels of caveolin-1 have been found to increase with aging, and reduction of caveolin-1 using antisense oligonucleotides or siRNA recovers the epidermal growth factor response in senescent cells. Rhim et al. hypothesized that caveolin-1-dependent responses in aged corneal epithelial cells may be responsible for delayed wound healing. The authors evaluated corneal wound healing time after laser epithelial keratomileusis (LASEK) surgery in young, middle aged and elderly patients. Results indicate caveolin-1 status may be responsible for delayed wound healing in the elderly and act as a regulator for wound healing capacity. While downregulation of caveolin-1 may facilitate wound healing in the elderly post LASEK surgery, these results may also be applied to wound healing in other surgeries or traumas.

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Posted by MolMed Admin on Dec 2, 2010 12:00 AM CST