Endoplasmic Reticulum Stress in Age-Related Macular Degeneration: Trigger for Neovascularization

Antero Salminen, Anu Kauppinen, Juha MT Hyttinen, Elisa Toropainen and Kai Kaarniranta

Age-related macular degeneration (AMD) can cause a progressive loss of central vision in elderly individuals. AMD may be classified into two categories: the atrophic dry form and the exudative wet form. The crucial difference between dry and wet AMD is the development of choroidal neovascularization in the wet form. In this review, Salminen et al. discuss the role of endoplasmic reticulum stress in neovascularization regulation and the conversion of dry age-related macular degeneration to its detrimental wet counterpart.

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Posted by MolMed Admin on Dec 3, 2010 12:00 AM CST