D-Chiro-Inositol Glycans in Insulin Signaling and Insulin Resistance

Joseph Larner, David L Brautigan, and Michael O Thorner

Classical actions of insulin involve increased glucose uptake from the bloodstream and its metabolism in peripheral tissues. However, non-oxidative and oxidative glucose disposal remain incompletely explained by current models for insulin action. In this work, Larner et al. review the possible role of second messengers in responses and resistance to insulin. The authors postulate that inositol glycans, particularly of the D-chiroinositol class, are insulin mimetic and may serve as insulin second messengers.

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Posted by MolMed Admin on Dec 4, 2010 12:00 AM CST