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Years and Volumes

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Articles from this Volume

Stephanie L Nott, Yanfang Huang, Aja Kaikanoglu, Kathryn Harper, Ming Chen, Scott F Paoni, Bruce M Fenton, and Mesut Muyan

Abnormalities in the growth and death programs of breast-ductal epithelial cells can lead to breast cancer, the initiation and progression of which can be influenced by 17β-estradiol (E2). Current treatments include reduction of circulating E2 and inhibition of estrogen receptor (ER) functions, approaches that are ineffective in de novo endocrine-resistant breast cancers. Nott et al. tested whether specific regulation of estrogen responsive element (ERE)-driven genes by the constitutively active transcription factor monotransregulator is a viable treatment alternative for this cancer. The authors found that the monotransregulator repressed cellular proliferation and motility and induced apoptosis by regularting ERE-driven gene expressions. Monotransregulators also limited xenograft tumor growth in nude mice. This study demonstrates the potential use of targeted regulation of endogenous genes for the treatment of cancers that are refractory to current approaches.

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Posted by MolMed Admin on Jan 2, 2010 12:00 AM CST
Christina Pipieri, Marios S Themistocieous, George A Papavassiliou, Elena Farmaki, Georgia Levidou, Penelope Korkolopoulou, Christos Adamopoulos, and Athanasios G Papavassiliou

The successful treatment of glioblastoma multiforme (GBM), a life-threatening intracranial malignant tumor, is hindered by difficulties in early diagnosis, rapid progression and frequent recurrence. Since the methylation status of specific gene loci can be used as a prognostic tool for different tumor types, Piperi et al. examined four genes involved in glioma tumorigenesis: MGMT, RARβ, RASSF1A and CDH13. The authors found that two of these genes, MGMT and RARβ were significantly more methylated in 70.58% and 58.8% of analysed GBM cases, respectively. This study also highlights a potential link between methylation patterns and IL-6, suggesting a specific role for inflammation mediators in the regulation of gene methylation. These results could generate new insight regarding patient survival and treatment options for this devastating disease.

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Posted by MolMed Admin on Jan 1, 2010 12:00 AM CST
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