Prevalence and Significance of Coagulation Abnormalities in Community-Acquired Pneumonia

Eric B Milbrandt, Michael C Reade, MinJae Lee, Stephanie L Shook, Derek C Angus, Lan Kong, Melinda Carter, Donald M Yealy, and John A Kellum, for the GenIMS Investigators
Although coagulation abnormalities are common in severe pneumonia and sepsis, little is known regarding the presence or significance of these aberrations in patients with lesser illness severity. In this study, Milbrandt et al. hypothesized that coagulation abnormalities would increase with illness severity and poor outcomes. They examined coagulation abnormalities in over 900 subjects hospitalized with community-acquired pneumonia and measured plasma coagulation markers at emergency department presentation and daily during the first week of hospitalization. The authors confirmed the existence of coagulation abnormalities in patients with pneumonia with severe sepsis. They also observed considerable abnormalities in community-acquired pneumonia patients who avoided organ dysfunction associated with severe sepsis. The observed heterogeneity in the coagulation response underscores the challenge of fine-tuning coagulation-based therapies to treat infection and severe sepsis.

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Posted by MolMed Editor on Dec 5, 2009 12:00 AM CST