Human Ghrelin Ameliorates Organ Injury and Improves Survival after Radiation Injury Combined with Severe Sepsis

Kavin G Shah, Rongqian Wu, Asha Jacob, Steven A Blau, Youxin Ji, Weifeng Dong, Corrado Marini, Thanjavur S Ravikumar, Gene F Cappa, and Ping Wang
Individuals exposed to radiation are likely to suffer from genetic mutations and additional injuries such as sepsis. Ghrelin, a human hormone found mostly in the stomach, is protective in models of sepsis. However, ghrelin had not been tested in a two-hit model of radiation combined injury (RCI). Shah et al. tested ghrelin in RCI and found that serum levels and gene expression in the stomach were markedly decreased 20 hours after injury. Administration of human ghrelin markedly attenuated tissue injury, reduced pro-inflammatory cytokine levels and improved survival. These results suggest that human ghrelin could be a safe and effective treatment against radiation combined injury.

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Posted by MolMed Editor on Dec 1, 2009 12:00 AM CST