Platelet Factor 4 Is Highly Upregulated in Dendritic Cells after Severe Trauma

Marcus Maier, Emanuel V Geiger, Dirk Henrich, Carolyn Bendt, Sebastian Wutzler, Mark Lehnert, and Ingo Marzi

Severe trauma induces a systemic inflammatory response that can eventually lead to remote organ dysfunction and failure. The innate immune system represents the first line of posttraumatic immune response, initiating further cellular activation. As a result of multiple traumatic injuries, two dendritic cell subtypes, myeloid (MDC) and plasmacytoid (PDC), are activated, with significant upregulation of platelet factor 4 (PF4) expression occurring during the first day. The potential clinical relevance of PF4 alteration in multiple trauma is unknown. To address this question, Maier et al. analyzed PF4 expression and phenotypic alterations of dendritic cells following multiple severe trauma. The authors found the intracellular PF4 content in MDCs and PDCs was significantly elevated in trauma patients when compared to control subjects. Further, they demonstrated that PF4 concentrations in MDCs and PDCs significantly correlated with the injury severity score (ISS). The results describe an early and enduring posttraumatic activation of PF4 in dendritic cells and shed light on the role PF4 plays in the posttraumatic immune response.

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Posted by MolMed Editor on Nov 3, 2009 12:00 AM CST