Inhibition of COX 1 and 2 prior to Renal Ischemia/Reperfusion Injury Decreases the Development of Fibrosis

Carla Q Feitoza, Giselle M Gonçalves, Patrícia Semedo,  Marcos A Cenedeze, Hélady S Pinheiro,  Felipe Caetano Beraldo, Oscar Fernando Pavão dos Santos, Vicente de Paula A Teixeira, Marlene A dos Reis, Marilda Mazzali, Alvaro Pacheco-Silva, and Niels O S Câmara

Ischemia and reperfusion injury (IRI) contributes to the development of chronic interstitial fibrosis/tubular atrophy in renal allograft patients. Cyclooxygenase (COX) 1 and 2 actively participate in acute ischemic injury by activating endothelial cells and inducing oxidative stress.  Blockade of COX 1 and 2 is associated with organ improvement after ischemic damage.  Feitoza et al. investigate the role of COX 1 and 2 in the development of fibrosis by performing COX 1 and 2 blockade immediately before IRI.  Inhibition of COX 1 and 2 resulted in less tissue fibrosis, which was associated with a decrease in proinflammatory cytokines and enhancement of the protective cellular response. The present work demonstrates that COXs play an important role in the development of sustained inflammation. There is no effective treatment for renal fibrosis and COX blockade prior to acute injury may represent a treatment strategy for renal damage associated with fibrosis.

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Posted by Leah Caracappa on Dec 3, 2008 12:00 AM CST