Acute, Muscle-Type Specific Insulin Resistance Following Injury

LaWanda H Thompson, Hyeong T Kim, Yuchen Ma, Natalia A Kokorina, and Joseph L Messina

Severe injuries such as surgical trauma, hemorrhage, thermal injury, and sepsis can lead to acute insulin resistance. The efficacy of intensive insulin therapy in these injuries suggests that understanding acute insulin resistance mechanisms may be important for development of new therapeutic strategies.  Thompson et al. used a surgical trauma and hemorrhage model to determine the development, timing and muscle selectivity of hemorrhage-induced skeletal muscle insulin resistance. The data indicate defects in insulin signaling occurred rapidly and were reversible. Additionally, insulin signaling was more severe in some skeletal muscles but did not occur in cardiac muscle. The mechanisms leading to recovering insulin responsiveness may be key in reducing morbidity and mortality in the intensive care environment.

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Posted by Leah Caracappa on Dec 2, 2008 12:00 AM CST