Angiogenesis and Diabetes: Different Responses to Pro-Angiogenic Factors in the Chorioallantoic Membrane Assay

Giovana S Di Marco, Antoine Alam, Frédéric Dol, Pierre Corvol, Jean-Marie Gasc, and Etienne Larger

Diabetic patients exhibit impaired angiogenesis often leading to difficulties in wound healing and organ transplantation. Therapeutic angiogenesis or arteriogenesis may represent a beneficial strategy for patients with diabetes as well as those with peripheral or coronary artery disease ineligible for surgical revascularization. Trials involving therapeutic angiogenesis have garnered negative responses due in part to the direct effect of hyperglycemia on neovascularization. To further investigate this, Di Marco et al. tested the activity of proangiogenic molecules under hyperglycemic conditions. Of the three molecules tested, results showed the negative effects of diabetes on capillary density could be overcome only by vascular endothelial growth factor (VEGF) overexpression. This suggests proangiogenic factors may play a role in patients with diabetes and future trials involving therapeutic angiogenesis should be monitored for hyperglycemic interference.

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Posted by Leah Caracappa on Dec 1, 2008 12:00 AM CST