Pancreatic Expression and Mitochondrial Localization of the Progestin-AdipoQ Receptor PAQR10

L Jorge Gonez, Gaetano Naselli, Ilia Banakh, Hideo Niwa, and Leonard C Harrison

Steroid hormones have been shown to rapidly modify cell function by binding to surface membrane receptors. In a screen for genes differentially expressed in mouse pancreatic β-cells, Góñez et al. identified a candidate steroid membrane receptor, the progestin and adipoQ receptor (PAQR) 10. PAQR10 is structurally related to bacterial hemolysins, pore-forming virulence factors that target mitochondria and regulate apoptosis. Góñez et al.propose PAQR10 may act at the level of the mitochondrion to regulate pancreatic endocrine cell development and survival, and further studies are likely to establish a key role of PAQR10 in pancreatic β-cell biology.

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Posted by Leah Caracappa on Nov 5, 2008 12:00 AM CST