Endogenous Erithropoietin as Part of the Cytokine Network in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Manuela Mengozzi, Ilaria Cervellini, Paolo Bigini, Sara Martone, Antonella Biondi, Rosetta Pedotti, Barbara Gallo, Sara Barbera, Tiziana Mennini, Mariaserena Boraso, Marina Marinovich, Edwige Petit, Myriam Bernaudin, Roberto Bianchi, Barbara Viviani, and Pietro Ghezzi

Systemically administered erythropoietin (EPO) crosses the blood brain barrier and is protective in several animal models of disease. Endogenous EPO is induced by hypoxic or ischemic injury, however, little is known regarding the expression of endogenous EPO in central nervous system (CNS) diseases.  Mengozzi et al. investigated the expression of EPO in the spinal cord using models of experimental autoimmune encephalomyelitis (EAE), representative of multiple sclerosis.  Their findings indicate EPO is induced in EAE and is negatively regulated by interferon gamma and tumor necrosis factor. This cross-talk between EPO and inflammatory cytokines in the CNS may have important implications in disease pathogenesis. Therapeutic exploitation strategies could be aimed at upregulating the endogenous EPO-mediated protective response.

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Posted by Leah Caracappa on Nov 3, 2008 12:00 AM CST