Inhibiting Proliferation and Enhancing Chemosensitivity to Taxanes in Osteosarcoma Cells by RNA Interference-Mediated Downregulation of Stathmin Expression

Rui Wang, Ke Dong, Fang Lin, Xi Wang, Ping Gao, San-Hua Wei, Shi-Yin Cheng, and Hui-Zhong Zhang

Osteosarcomas, the most frequently occurring type of bone tumor, are malignant tumors derived from bone tissues.  Osteosarcomas are characterized by aggressive invasion, early metastasis and resistance to existing chemotherapeutic agents.  Novel diagnostic and treatment approaches are needed to improve the poor prognosis of osteosarcoma.  The stathmin family of proteins is important in signal transduction and is highly expressed in human osteosarcoma.  Here, Wang et al. (567-575) investigate stathmin as a therapeutic target by using osteosarcoma RNA interference to reduce stathmin expression in human osteosarcoma cell lines.  Downregulation of stathmin expression significantly inhibited osteosarcoma cell proliferation in vitro, tumorgenicity in vivo, enhanced apoptosis and enhanced chemosensitivity to taxanes in human osteosarcoma cell lines.  These data indicate that RNA interference-mediated stathmin downregulation exerts potent anti-proliferative and chemosensitizing effects in human osteosarcomas.

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Posted by Leah Caracappa on Apr 2, 2012 5:03 PM CDT