Altered FOXO1 Transcript Levels in Peripheral Blood Mononuclear Cells of Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients

Chia-Chen Kuo and Shih-Chang Lin

The members of the forkhead box class O (FOXO) transcription factors (FOXO1, FOXO3a, and FOXO4) play an important role in controlling lymphocyte activation and proliferation.  Kuo and Lin (561-566) evaluated the possibility that FOXO transcriptional expression is dysregulated in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), two autoimmune diseases with tissue damage mediated by overactivation of autoreactive lymphocytes.  Kuo and Lin determined quantities of FOXO forkhead transcription factors in peripheral blood mononuclear cells from control, SLE and RA patients.  Their results show differential regulation of FOXO1 in SLE and RA patients when compared with control subjects. The data suggest transcriptional dysregulation in FOXO1 may be linked with the pathogenesis of autoimmune disease and that FOXO1 transcript levels in peripheral blood may serve as a biomarker for disease activity.

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Posted by Leah Caracappa on Apr 2, 2012 5:04 PM CDT