Fractalkine-Induced MFG-E8 Leads to Enhanced Apoptotic Cell Clearance by Macrophages

Michael Miksa, Dhruv Amin, Rongqian Wu, Weifeng Dong, Thanjavur S Ravikumar, and Ping Wang

Sepsis is a systemic inflammatory response to infection which may lead to multiple organ failure and is associated with increased rates of apoptosis. Clearance of apoptotic cells is crucial to maintaining cellular function under normal and pathological conditions. Administration of exosomes, derived from immature dendritic cells, promotes phagocytosis of apoptotic cells and improves survival in an animal model of sepsis by providing milk fat globule epidermal growth factor-factor VIII (MFG-E8). In this work, Miksa et al. (553-560) investigate whether the CX3CL1-chemokine fractalkine (CX3CL1) plays a role in apoptotic cell clearance. Their results show that CX3CL1 induces MFG-E8 in vitro and in vivo and enhances clearance of apoptotic cells in an MFG-E8 dependent manner. These findings suggest a possible novel treatment for patients with sepsis.

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Posted by Leah Caracappa on Apr 2, 2012 5:05 PM CDT