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Years and Volumes

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Molecular Medicine Volume 12

Articles from this Volume

Peter W Hewett, Emma L Daft, Charles A Laughton, Shakil Ahmad, Asif Ahmed, and J Clifford Murray
 
Angigogenesis is essential for the growth of tumors and the development of hematological metastases.   Tie receptors, which are up-regulated during angigogeneis, play a fundamental role in vascular remodeling.  Inhibition of Tie receptors disrupts angigogenesis and can subsequently prevent tumor growth.  Hewett et al. (pages 8-16) provide evidence that an anti-gene approach, which targets Ets binding sites can selectively inhibit Tie-1 gene promoter activity in endothelial cells.  As similar Ets binding sites are important in the regulation of several endothelial restricted genes, this approach may have broad therapeutic potential for cancer and pathologies involving endothelial cell proliferation and dysfunction.

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Posted by MolMed Editor on Feb 1, 2006 12:00 AM CST

Karin List, Thomas H Bugge, and Roman Szabo

Matriptase, a type II transmembrane serine protease and its cognate transmembrane inhibitor, hepatocyte growth factor activator inhibitor (HAI)-1 play physiological roles in the epithelium, epidermis, and hair follicle growth.  Matriptase and HAI expression are frequently dysregulated in human cancer and when unopposed by HAI-1, matriptase promotes carcinogenesis and metastatic dissemination in animal models.  In an invited review, List et al. (pages 1-7) describe the biochemistry, physiology, and pathology of this complex cell surface serine protease.

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Posted by Leah Caracappa on Jan 2, 2006 12:00 AM CST
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