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Years and Volumes

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Molecular Medicine Volume 11

Articles from this Volume

Mei Qi, Ann E Anderson, Da-Zhi Chen, Shishinn Sun, Karen J Auborn

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Posted by MolMed Admin on Dec 31, 2012 10:23 AM CST
Chrysoula Belessi, Kostas Stamatopoulos, Anastasia Hadzidimitriou, Katerina Hatzi, Tatjana Smilevska, Niki Stavroyianni, Fotini Marantidou, George Paterakis, Athanasios Fassas, Achilles Anagnostopoulos, Nikolaos Laoutaris

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Posted by MolMed Admin on Dec 1, 2005 12:00 AM CST
Valentina Paracchini, Seymour Garte, Paola Pedotti, Francesca Poli, Sara Frison, and Emanuela Taioli 

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Posted by MolMed Admin on Jun 1, 2005 12:00 AM CDT
Lei Zhang, Shannon P Reidy, Tara E Nicholson, Hyun-Jeong Lee, Amin Majdalawieh, Chris Webber, Bruce R Stewart, Peter Dolphin, and Hyo-Sung Ro

Obesity is an important risk factor for heart disease, diabetes, and certain cancers, but the molecular basis for obesity is poorly understood. The transcriptional repressor AEBP1, which functions as a negative regulator of PTEN through a protein–protein interaction, is highly expressed in the stromal compartment of adipose tissues, including proliferative preadipocytes, and its expression is abolished in terminally differentiated, nonproliferative adipocytes. Here we show that transgenic overexpression of AEBP1 during adipogenesis coupled with a high-fat diet (HFD) resulted in massive obesity in female transgenic (AEBP1TG) mice via adipocyte hyperplasia. AEBP1 levels dynamically changed with aging, and HFD induced AEBP1 expression in females. Thus, HFD-fed AEBP1TG females display hyperinduction of AEBP1 and a marked reduction of PTEN level with concomitant hyperactivation of the survival signal in white adipose tissue. Our results suggest that AEBP1 plays a key functional role in in vivo modulation of adiposity via fatcell proliferation and is involved in a sex-specific susceptibility to diet-induced obesity by the estrogen signaling pathway. 

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Posted by MolMed Admin on May 1, 2005 12:00 AM CDT
Nicoletta Gagliano, Carlo Torri, Elena Donetti, Fabio Grizzi, Francesco Costa, Alberto AE Bertelli, Massimiliano Migliori, Cristina Filippi, Marzia Bedoni, Vincenzo Panichi, Luca Giovannini, Magda Gioia

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Posted by MolMed Admin on Apr 1, 2005 12:00 AM CST
Franak M Batliwalla, Wentian Li, Christopher T Ritchlin, Xiangli Xiao, Max Brenner, Teresina Laragione, Tianmeng Shao, Robert Durham, Sunil Kemshetti, Edward Schwarz, Rodney Coe, Marlena Kern, Emily C Baechler, Timothy W Behrens, Peter K Gregersen, Pércio S Gulko

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Supplementary Data File Il: PDF
Posted by MolMed Admin on Mar 1, 2005 12:00 AM CST
Stéphane Potteaux, Christophe Combadière, Bruno Esposito, Saveria Casanova, Régine Merval, Patrice Ardouin, Ji-Liang Gao, Philip M Murphy, Alain Tedgui, and Ziad Mallat

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Posted by MolMed Admin on Feb 1, 2005 12:00 AM CST

Flavio Leoni, Gianluca Fossati, Eli C Lewis, Jae-Kwon Lee, Giulia Porro, Paolo Pagani, Daniela Modena, Maria Lusia Moras, Pietro Pozzi, Leonid L Reznikov, Britta Siegmund, Giamila Fantuzzi, Charles A Dinarello, and Paolo Mascagni

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Posted by MolMed Admin on Jan 1, 2005 12:00 AM CST