Angiopoietin-1 Protects Heart against Ischemia/Reperfusion Injury through VE-Cadherin Dephosphorylation and Myocardiac Integrin-β1/ERK/Caspase-9 Phosphorylation Cascade

Sae-Won Lee, Joo-Yun Won, Hae-Young Lee, Ho-Jae Lee, Seock-Won Youn, Ji-Young Lee, Chung-Hyun Cho, Hyun-Jai Cho, Seil Oh, In-Ho Chae, and Hyo-Soo Kim

Prolonged periods of myocardial ischemia may lead to irreversible cardiomyocyte and vasculature loss, which can disrupt cardiac integrity and function. Early reperfusion is the dominant clinical strategy for myocardial salvage. Unfortunately, while early reperfusion is essential for tissue salvage, it also causes myocardial and vascular injury. Angopoietin-1 is an endothelial-specific angiogenic factor known to regulate vessel formation and maintenance of endothelial integrity. The possible effect of angiopoietin-1 on cardiomyocytes and vascular cells during reperfusion has not yet been investigated. To test the protective mechanism of angiopoietin-1, Lee et al. employed a model of myocardial ischemia/reperfusion. The authors show angiopoietin-1 promotes both endothelial integrity and cardiomyocyte survival. The data suggest angopoietin-1 is a prospective therapeutic candidate to preserve myocardial function after reperfusion injury.

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Posted by Leah Caracappa on Oct 12, 2011 12:00 AM CDT