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T Cell Suppression by Trimolecular Coplex of CD52, HMGB1 and Siglec-10

Esther Bandala-Sanchez, PhD, of The Walter and Eliza Hall Institute of Medical Research in Australia discusses the role HMGB1 plays in the binding of CD52 and Siglec-10, how T cells expressing high levels of CD52 contribute to immune homeostasis preventing development of autoimmune disease, and the therapeutic potential CD52 has as an immune-suppressive agent.

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